|
KMID : 0880520100460020067
|
|
Chonnam Medical Journal
2010 Volume.46 No. 2 p.67 ~ p.73
|
|
|
Sirt1 as a New Therapeutic Target in Metabolic and Age-Related Diseases
|
|
Lee Dae-Ho
|
|
|
Abstract
|
|
|
|
Sirt1 among the mammalian sirtuins has generated intense scientific interest in recent years, mainly because of its effects on longevity, metabolism, and other aging-related processes. Via nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylation, Sirt1 can regulate important metabolic regulators. Sirt1 is involved in insulin secretion in the pancreas, fatty acid oxidation in liver and skeletal muscle, hepatic gluconeogenesis during fasting, the suppression of fat storage in white adipose tissue, and the enhancement of insulin sensitivity in skeletal muscle. It also communicates with AMP-activated protein kinase (AMPK). Resveratrol, a prototype of Sirt1 activator, can induce similar changes reminiscent of caloric restriction in insulin-resistant obese rodent models, although clinical studies are still limited. Intensive research efforts are now targeting Sirt1 for pharmacologic interventions in aging and age-related metabolic and degenerative disorders.
|
|
|
KEYWORD
|
|
|
Sirt1, AMP-activated protein kinases, Caloric restriction, Longevity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|